|Former Common name
|ES Cell line
|Developed by Hiroaki Honda, Research Institute for Radiation Biology and Medicine and Junko Takita, The University of Tokyo Hospital. A F1174L mutant hALK gene under the TH promoter was injected into the pronuclei of C57BL/6N fertilized eggs.
|Human ALK (anaplastic lymphoma kinase) gene having F1174L mutation transgenic mice. F1174L mutation was identified in a patient with an inflammatory myofibroblastic tumor harboring a RANBP2-ALK translocation.
|Nature, 455, 971-974 (2008). 18923524
|Examination Date / Room / Rack
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
ALKhuman ALK cDNA (F1174L mutant)UNALKhuman tyrosine hydroxylase promoter
|human tyrosine hydroxylase promoter, human ALK cDNA (F1174L mutant), rabbit beta globin intron, Herpes simplex virus HSV terminator
Mouse Models for Human Disease
|Specific Term and Conditions
|Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
|Hiroaki Honda (Tokyo Women's Medical University)
|Recovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
|Genotyping protocol -PCR-
Necessary documents for ordering:
BRC mice in Publications