RBRC05203

Information1

Image
BRC No.RBRC05203
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(TH-ALK*F1174L)5Homy
Former Common nameB6-Th-ALK/F1174L Tg#5L
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Hiroaki Honda, Research Institute for Radiation Biology and Medicine and Junko Takita, The University of Tokyo Hospital. A F1174L mutant hALK gene under the TH promoter was injected into the pronuclei of C57BL/6N fertilized eggs.
Strain descriptionHuman ALK (anaplastic lymphoma kinase) gene having F1174L mutation transgenic mice. F1174L mutation was identified in a patient with an inflammatory myofibroblastic tumor harboring a RANBP2-ALK translocation.
Colony maintenance
ReferencesNature, 455, 971-974 (2008). 18923524

Health Report

Examination Date / Room / Rack2013/04/15Room:3-CRack:F
2013/02/18Room:3-CRack:F
2012/12/10Room:3-CRack:F
2012/10/15Room:3-CRack:F
2012/08/27Room:3-CRack:F

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
ALKhuman ALK cDNA (F1174L mutant)UNALKhuman tyrosine hydroxylase promoter

Information2

Donor DNAhuman tyrosine hydroxylase promoter, human ALK cDNA (F1174L mutant), rabbit beta globin intron, Herpes simplex virus HSV terminator
Research applicationCancer Research
Mouse Models for Human Disease
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHiroaki Honda (Tokyo Women's Medical University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data