Strain Data Sheet

RBRC05197

Strain Information

Image
BRC No.RBRC05197
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Mll1<tm1Tok>
Former Common nameMll KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Hideshi Yagi and Toshihisa Komori, Osaka University Medical School in 1998.
Strain descriptionMll1 knockout mice. Homozygous mutant mice are embryonic lethal (E11) due to hematopoietic disorder. Heterozygous mice show somewhat poor growth compared to wild-type.
Colony maintenanceHeterozygote X Wild-type [C57BL/6J]
References
Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.
Yagi H, Deguchi K, Aono A, Tani Y, Kishimoto T, Komori T
Blood, 92, 108-117 (1998). 9639506

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mll1myeloid/lymphoid or mixed-lineage leukemia 19Mll1targeted mutation 1, Toshihisa Komori
  • Wiedemann-Steiner syndrome(MedGEN)
    • neoneomycin resistance gene (E. coli)9mouse phosphoglycerate kinase promoter (PGK promoter)
  • Wiedemann-Steiner syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • skeleton phenotype(MP:0005390)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli Neomycin resistance gene, Mouse Mll gene genome, Mouse phosphoglycerate kinase promoter, SV40 PolyA signal
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Blood, 92, 108-117 (1998).RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorMakoto Sato (University of Fukui)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data