Strain Data Sheet

RBRC05138

Strain Information

Image
BRC No.RBRC05138
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129S6-Trpm1<tm1Tfur>
Former Common name129-Trpm1 KO
H-2 Haplotype
ES Cell lineTC1 [129S6/SvEvTac]
Background strain129S6/SvEvTac
Appearance
Strain developmentDeveloped by Takahisa Furukawa, Osaka Bioscience Institute in 2005. A neomycin selection cassette was inserted into the exon 4-6 of the TRPM1 gene. 129 background.
Strain descriptionTrpm1 knockout mice. A neomycin selection cassette was inserted into the exon 4-6 of the TRPM1 gene.
Colony maintenanceHomozygote x Homozygote
References
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.
Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, Furukawa T
Proc. Natl. Acad. Sci. USA, 107, 332-337 (2010). 19966281

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
SV40 polyA signal7
  • congenital stationary night blindness 1C(MedGEN)
    • Trpm1transient receptor potential cation channel, subfamily M, member 17Trpm1targeted mutation 1, Takahisa Furukawa
  • congenital stationary night blindness 1C(MedGEN)
    • neoneomycin resistance gene (E. coli)7
  • congenital stationary night blindness 1C(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal cone electrophysiology(MP:0004022)

  • abnormal rod electrophysiology(MP:0004021)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse PGK promoter, E. coli Neomycin resistance gene, SV40 PolyA signal
    Research applicationMouse Models for Human Disease
    Sensorineural Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 107, 332-337(2010). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).
    DepositorTakahisa Furukawa (Osaka Bioscience Institute)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month Sep 2011

    BRC mice in Publications

    No Data