Strain Data Sheet

RBRC05131

Strain Information

Image
BRC No.RBRC05131
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameD1;129S2-Il6<tm1Kopf>
Former Common name
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain developmentDeveloped by Manfred Kopf, Max-Planck-Institut fur Immunbiologie in 1994. The mice were backcrossed to DBA/1 for at least 4 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo.
Strain descriptionIL-6 knockout mice. Homozygous mutant mice show decreased immune competence. slight overweight with aging.
Colony maintenance
References
Impaired immune and acute-phase responses in interleukin-6-deficient mice.
Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, Zinkernagel R, Bluethmann H, Kohler G
Nature, 368, 339-342 (1994). 8127368

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Il6
MGI:96559		interleukin 65Il6<tm1Kopf>
MGI:1857197		targeted mutation 1, Manfred Kopf
  • arteriovenous malformations of the brain(MedGEN)

  • inflammatory bowel disease 1(MedGEN)

  • Kaposi sarcoma, susceptibility to(MedGEN)
    • more 3 Diseases
  • systemic-onset juvenile idiopathic arthritis(MedGEN)

  • type 1 diabetes mellitus(MedGEN)

  • type 2 diabetes mellitus(MedGEN)
    • neo neomycin resistance gene (E. coli)5 herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    SV40 polyA5

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal CNS glial cell morphology (MP:0000952)

  • abnormal T cell differentiation (MP:0002145)

  • abnormal T cell physiology (MP:0002444)

  • abnormal acute phase protein level (MP:0010211)

  • abnormal astrocyte morphology (MP:0002182)
    • more 71 phenotypes
  • abnormal axon morphology (MP:0005404)

  • abnormal bone healing (MP:0002999)

  • abnormal brain interneuron morphology (MP:0004101)

  • abnormal capillary morphology (MP:0003658)

  • abnormal cardiovascular system physiology (MP:0001544)

  • abnormal emotion/affect behavior (MP:0002572)

  • abnormal exercise endurance (MP:0002332)

  • abnormal frequency of paradoxical sleep (MP:0003194)

  • abnormal glial cell morphology (MP:0003634)

  • abnormal glucose homeostasis (MP:0002078)

  • abnormal heart development (MP:0000267)

  • abnormal heart morphology (MP:0000266)

  • abnormal heart ventricle morphology (MP:0005294)

  • abnormal homeostasis (MP:0001764)

  • abnormal inflammatory response (MP:0001845)

  • abnormal inhibitory learning (MP:0020340)

  • abnormal interleukin-6 secretion (MP:0008704)

  • abnormal interventricular septum morphology (MP:0000281)

  • abnormal involution of the mammary gland (MP:0006271)

  • abnormal learning/memory/conditioning (MP:0002063)

  • abnormal long-term object recognition memory (MP:0002801)

  • abnormal microglial cell morphology (MP:0000136)

  • abnormal muscle precursor cell migration (MP:0003090)

  • abnormal nervous system physiology (MP:0003633)

  • abnormal neuron morphology (MP:0002882)

  • abnormal neuron physiology (MP:0004811)

  • abnormal object recognition memory (MP:0001458)

  • abnormal oval cell physiology (MP:0010042)

  • abnormal oxygen consumption (MP:0005288)

  • abnormal pancreatic alpha cell mass (MP:0030587)

  • abnormal pancreatic alpha cell morphology (MP:0005216)

  • abnormal pulmonary gas exchange (MP:0002336)

  • abnormal skeletal muscle fiber morphology (MP:0003084)

  • abnormal skeletal muscle satellite cell proliferation (MP:0009410)

  • abnormal sleep pattern (MP:0001501)

  • abnormal spatial learning (MP:0001463)

  • behavioral despair (MP:0002573)

  • decreased T cell number (MP:0005018)

  • decreased body weight (MP:0001262)

  • decreased bone mineral density (MP:0000063)

  • decreased cardiac muscle contractility (MP:0005140)

  • decreased cytotoxic T cell cytolysis (MP:0005079)

  • decreased glucagon secretion (MP:0002711)

  • decreased heart weight (MP:0002834)

  • decreased incidence of tumors by chemical induction (MP:0004502)

  • decreased insulin secretion (MP:0003059)

  • decreased interferon-gamma secretion (MP:0008567)

  • decreased interleukin-17 secretion (MP:0008682)

  • decreased pro-B cell number (MP:0008208)

  • decreased susceptibility to induced arthritis (MP:0003436)

  • decreased susceptibility to injury (MP:0005166)

  • delayed wound healing (MP:0002908)

  • dilated heart left ventricle (MP:0002753)

  • hepatic necrosis (MP:0001654)

  • hyperactivity (MP:0001399)

  • impaired glucose tolerance (MP:0005293)

  • impaired wound healing (MP:0001792)

  • increased anxiety-related response (MP:0001363)

  • increased body temperature (MP:0005533)

  • increased circulating glucose level (MP:0005559)

  • increased fear-related response (MP:0003459)

  • increased interleukin-4 secretion (MP:0008699)

  • increased susceptibility to bacterial infection (MP:0002412)

  • increased susceptibility to bacterial infection induced morbidity/mortality (MP:0009788)

  • increased susceptibility to induced colitis (MP:0008537)

  • increased susceptibility to viral infection (MP:0002418)

  • liver degeneration (MP:0003103)

  • obese (MP:0001261)

  • retina outer nuclear layer degeneration (MP:0008518)

  • seizures (MP:0002064)

  • thin ventricular wall (MP:0000280)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), Neomycin resistance gene (E. coli), PolyA signal (SV40), mouse Il6 genomic DNA
    Research applicationImmunology and Inflammation Research
    covid19_onset
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 368, 339-342 (1994).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorYoichiro Iwakura (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data