Strain Data Sheet


Strain Information

BRC No.RBRC05130
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameD1;129S2-Il4<tm1Kopf>
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Manfred Kopf, Max-Planck-Institut fur Immunbiologie in 1993. The mice were backcrossed to DBA/1 for at least 4 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo.
Strain descriptionIL-4 knockout mice. Homozygous mutant mice show increased susceptibility to infection of parasites.
Colony maintenance
ReferencesNature, 362, 245-248 (1993). 8384701

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Il4interleukin 411Il4<tm1Kopf>targeted mutation 1, Manfred Kopf

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)11neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Ordering Information

Donor DNANeomycin resistance gene (E. coli), PolyA signal (SV40), MC1 promoter (HSV)
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 362(6417):245-248 (1993).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DepositorYoichiro Iwakura (The University of Tokyo)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data