Strain Data Sheet

RBRC04940

Strain Information

Image
BRC No.RBRC04940
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.B6D2-Tg(Ins2-Tnf)
Former Common nameB6-Ins2-Tnf Tg (TNF-Tg)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yasunori Higuchi, Centre Medical Unibersitaire, University oF Geneva in 1990.
Strain description
Colony maintenanceCarrier x Noncarrier [C57BL/6NJcl]
References
Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.
Higuchi Y, Herrera P, Muniesa P, Huarte J, Belin D, Ohashi P, Aichele P, Orci L, Vassalli J D, Vassalli P
J. Exp. Med., 176, 1719-1731 (1992). 1460428

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.
Ohashi P S, Oehen S, Aichele P, Pircher H, Odermatt B, Herrera P, Higuchi Y, Buerki K, Hengartner H, Zinkernagel R M
J. Immunol., 150, 5185-5194 (1993). 8496610

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tnftumor necrosis factorUNTnfrat Insulin prommoter 2, SV40 polyA signal
  • diabetes mellitus, permanent neonatal 4(MedGEN)

  • hyperproinsulinemia(MedGEN)

  • inherited susceptibility to asthma(MedGEN)
    • more 6 Diseases
  • malaria, susceptibility to(MedGEN)

  • maturity-onset diabetes of the young type 10(MedGEN)

  • maturity-onset diabetes of the young(DisGeNET)

  • migraine with or without aura, susceptibility to, 1(MedGEN)

  • permanent neonatal diabetes mellitus(DisGeNET)

  • type 1 diabetes mellitus 2(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal pancreatic islet morphology(MP:0005215)

  • homeostasis/metabolism phenotype(MP:0005376)

  • immune system phenotype(MP:0005387)

  • insulitis(MP:0004031)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse TNF-alpha genomic DNA, Rat Insulin prommoter 2, SV40 polyA signal
    Research applicationDiabetes and Obesity Research
    covid19_onset
    covid19_progression
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorYasunori Higuchi (Oita University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data