Strain Data Sheet


Strain Information

BRC No.RBRC04937
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S4-Atrx<tm1Enl>
Former Common nameB6-Atrx KO (ATRX<deltaE2>)
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Strain developmentDeveloped by Hideyuki Beppu and En Li, Massachusetts General Hospital, Harvard Medical School.
Strain description
Colony maintenanceHeterozygote (female), Hemizygote (male) x Wild-type [C57BL/6JJmsSlc]
ReferencesHippocampus, 21, 678-687 (2011). 20865721
J. Neurosci., 31, 346-358 (2011). 21209221

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)XAtrx<tm1Enl>targeted mutation 1, En Li

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
IRESinternal ribosomal entry site (EMCV)Xinternal ribosomal entry site from EMCV

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)X

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)Xneo; neomycin;

Ordering Information

Donor DNAMouse En-2 splicing acceptor, Encephalomyocarditis virus Internal ribosome-entry site, E. coli LacZ, E. coli Neomycin resistance gene, SV40 PolyA signal
Research applicationMouse Models for Human Disease
Neurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested. Hippocampus. 2011 21(6):678-87. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and Massachusetts General Hospital (Boston, USA) and must obtain a prior written consent from the DEPOSITOR and Massachusetts Genearal Hospital.
DepositorHideyuki Beppu (University of Toyama)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Shioda N, Yabuki Y, Yamaguchi K, Onozato M, Li Y, Kurosawa K, Tanabe H, Okamoto N, Era T, Sugiyama H, Wada T, Fukunaga K.
Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome.
Nat Med 24(6) 802-813(2018) 29785027