Strain Data Sheet

RBRC04922

Strain Information

Image
BRC No.RBRC04922
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S7-Ifngr1<tm1Agt>
Former Common name
H-2 Haplotype
ES Cell lineAB1 [129S7/SvEvBrd-Hprt<+>]
Background strain
Appearance
Strain developmentDeveloped by Michel Aguet, Institute of Molecular Biology I, University of Zurich in 1993. C57BL/6 background. Maintained by The Institute of Medical Science, The University of Tokyo.
Strain descriptionIFN gamma 1 knockout mice. Homozygous mutant mice show increased susceptibility to infection.
Colony maintenance
References
Immune response in mice that lack the interferon-gamma receptor.
Huang S, Hendriks W, Althage A, Hemmi S, Bluethmann H, Kamijo R, Vilcek J, Zinkernagel R M, Aguet M
Science, 259, 1742-1745 (1993). 8456301

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ifngr1
MGI:107655		interferon gamma receptor 110Ifngr1<tm1Agt> targeted mutation 1, Michel Aguet
  • autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency(MedGEN)

  • Helicobacter pylori infection, susceptibility to(MedGEN)

  • hepatitis B virus, susceptibility to(MedGEN)
    • more 2 Diseases
  • immunodeficiency 27A(MedGEN)

  • obsolete Mycobacterium tuberculosis, susceptibility to(MedGEN)
    • neo neomycin resistance gene (E. coli)10 herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    SV40 polyA signal10

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal circulating chemokine level (MP:0010209)

  • abnormal circulating osteocalcin level (MP:0011922)

  • abnormal cytotoxic T cell physiology (MP:0005078)

  • abnormal depression-related behavior (MP:0003360)

  • abnormal hematopoietic system physiology (MP:0001545)
    • more 57 phenotypes
  • abnormal immunoglobulin level (MP:0002490)

  • abnormal lymphopoiesis (MP:0002401)

  • abnormal maternal decidual layer morphology (MP:0004256)

  • abnormal myelination (MP:0000920)

  • abnormal osteocyte morphology (MP:0008753)

  • abnormal pain threshold (MP:0001970)

  • abnormal response to infection (MP:0005025)

  • abnormal tumor susceptibility (MP:0002166)

  • abnormal tumor vascularization (MP:0010144)

  • abnormal uterine NK cell morphology (MP:0008054)

  • abnormal uterine NK cell physiology (MP:0009099)

  • abnormal uterus morphology (MP:0001120)

  • abnormal vascular endothelial cell physiology (MP:0004003)

  • aortitis (MP:0010139)

  • arteritis (MP:0010138)

  • decreased CD4-positive, alpha-beta T cell number (MP:0008075)

  • decreased CD8-positive, alpha-beta T cell number (MP:0008079)

  • decreased IgG2a level (MP:0008496)

  • decreased IgG3 level (MP:0008498)

  • decreased bone marrow cell number (MP:0000333)

  • decreased bone mineralization (MP:0020137)

  • decreased bone ossification (MP:0020040)

  • decreased bone resorption (MP:0004993)

  • decreased bone trabecula number (MP:0010869)

  • decreased bone volume (MP:0010876)

  • decreased circulating interleukin-12 level (MP:0008618)

  • decreased circulating tumor necrosis factor level (MP:0008554)

  • decreased compact bone thickness (MP:0000135)

  • decreased lymphocyte cell number (MP:0005016)

  • decreased osteoblast cell number (MP:0004989)

  • decreased osteocyte number (MP:0030483)

  • decreased physiological sensitivity to xenobiotic (MP:0008874)

  • decreased susceptibility to endotoxin shock (MP:0008734)

  • decreased susceptibility to experimental autoimmune myasthenia gravis (MP:0004824)

  • decreased trabecular bone thickness (MP:0009346)

  • impaired osteoblast differentiation (MP:0011711)

  • increased circulating interleukin-6 level (MP:0008596)

  • increased hepatocyte proliferation (MP:0003893)

  • increased interferon-gamma secretion (MP:0008566)

  • increased interleukin-6 secretion (MP:0008705)

  • increased metastatic potential (MP:0001272)

  • increased splenocyte proliferation (MP:0009336)

  • increased susceptibility to bacterial infection (MP:0002412)

  • increased susceptibility to bacterial infection induced morbidity/mortality (MP:0009788)

  • increased susceptibility to experimental autoimmune encephalomyelitis (MP:0004799)

  • increased susceptibility to experimental autoimmune uveoretinitis (MP:0004821)

  • increased susceptibility to graft versus host disease (MP:0005672)

  • increased susceptibility to induced arthritis (MP:0003724)

  • increased susceptibility to induced morbidity/mortality (MP:0009763)

  • increased susceptibility to parasitic infection (MP:0005027)

  • increased susceptibility to viral infection (MP:0002418)

  • increased susceptibility to viral infection induced morbidity/mortality (MP:0009791)

  • increased tumor necrosis factor secretion (MP:0008560)

  • increased uterine NK cell number (MP:0009394)

  • liver abscess (MP:0003332)

  • osteoporosis (MP:0000066)

  • spleen hypoplasia (MP:0000694)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli Neomycin resistance gene, SV40 PolyA signal, mouse Ifngr1 genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Science, 259, 1742-1745 (1993). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorYoichiro Iwakura (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data