Strain Information | |
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Image | |
BRC No. | RBRC04921 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | C;129S2-Il4<tm1Kopf> |
Former Common name | C.129S2-Il4<tm1Kopf> |
H-2 Haplotype | |
ES Cell line | D3 [129S2/SvPas] |
Background strain | |
Appearance | |
Strain development | Developed by Manfred Kopf, Max-Planck-Institut fur Immunbiologie in 1993. The mice were backcrossed to BALB/c for at least 7 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo. |
Strain description | IL-4 knockout mice. Homozygous mutant mice show increased susceptibility to parasitic infection. |
Colony maintenance | |
References | Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Kopf M, Le Gros G, Bachmann M, Lamers M C, Bluethmann H, Kohler G Nature, 362, 245-248 (1993). 8384701 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Il4 MGI:96556 | interleukin 4 | 11 | Il4<tm1Kopf> MGI:2176268 | targeted mutation 1, Manfred Kopf | |||
neo | neomycin resistance gene (E. coli) | 11 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||
SV40 polyA | 11 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 6 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), Neomycin resistance gene (E. coli), PolyA signal (SV40), mouse Il4 genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 362(6417):245-248 (1993).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Yoichiro Iwakura (The University of Tokyo) |
Strain Status | ![]() |
Strain Availability | ![]() |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |