Strain Data Sheet

RBRC04914

Strain Information

Image
BRC No.RBRC04914
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC3H/HeN-Tg(CD4-HIVvpr)3311Yiw
Former Common name
H-2 Haplotype
ES Cell line
Background strainC3H/HeNSlc
Appearance
Strain developmentDeveloped by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo in 2001. C3H background.
Strain descriptionT cell specific HIV vpr transgenic mice. Tg mice show thymic atrophy and increased apoptosis of T cells.
Colony maintenance
References
T cell apoptosis causes peripheral T cell depletion in mice transgenic for the HIV-1 vpr gene.
Yasuda J, Miyao T, Kamata M, Aida Y, Iwakura Y
Virology, 285, 181-192 (2001). 11437653

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
HIVhuman immunodeficiency virusUNHIVCd4 antigen promoter
  • immunodeficiency 79(MedGEN)

  • Okt4 epitope deficiency(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal lymphocyte cell number(MP:0000717)

  • decreased CD4-positive, alpha-beta T cell number(MP:0008075)

  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • decreased double-positive T cell number(MP:0005092)

  • decreased thymocyte number(MP:0000715)
    • more 3 phenotypes
  • increased double-negative T cell number(MP:0005090)

  • increased thymocyte apoptosis(MP:0009541)

  • small thymus(MP:0000706)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Cd4 promoter, HIV vpr
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Virology, 285, 181-192 (2001).Please obtain the written consent from Professor Yoichiro Iwakura (iwakura@rs.tus.ac.jp; Research Institute for Biological Sciences, Tokyo University of Science) for the use.
    DepositorYoichiro Iwakura (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data