Strain Data Sheet

RBRC04907

Strain Information

Image
BRC No.RBRC04907
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC.C3B6-Tg(HTLV-I/LTR-pX)647Yiw
Former Common name
H-2 Haplotype
ES Cell line
Background strainBALB/cAJcl
Appearance
Strain developmentDeveloped by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo in 1991. Transgene was injected into the pronuclei of B6C3F1 fertilized eggs. BALB/c background.
Strain descriptionTransgenic mice having env-pX region of human T cell leukemia virus type-I (HTLV-I). Tg mice develop chronic arthritis resembling rheumatoid arthritis. BALB/c background.
Colony maintenance
References
Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I.
Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, Kitajima I, Nishioka K, Yamamoto K, Takeda T, Hatanaka M, et a l
Science, 253, 1026-1028 (1991). 1887217

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
HTLV-Ienv-pX region (HTLV-I)UNHTLV-I

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal ankle joint morphology(MP:0030835)

  • abnormal cartilage morphology(MP:0000163)

  • abnormal digit morphology(MP:0002110)

  • abnormal joint morphology(MP:0002932)

  • abnormal knee joint morphology(MP:0030837)
    • more 14 phenotypes
  • abnormal synovial joint morphology(MP:0030804)

  • arthritis(MP:0002993)

  • chronic joint inflammation(MP:0002935)

  • increased T cell proliferation(MP:0005348)

  • increased anti-double stranded DNA antibody level(MP:0004762)

  • increased anti-single stranded DNA antibody level(MP:0004771)

  • increased fibroblast cell migration(MP:0011709)

  • increased foot pad temperature(MP:0011993)

  • increased lymphocyte cell number(MP:0005013)

  • increased macrophage cell number(MP:0005425)

  • increased neutrophil cell number(MP:0000219)

  • joint swelling(MP:0002936)

  • rheumatoid arthritis(MP:0003561)

  • small thymus(MP:0000706)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman T cell leukemia virus type-I (HTLV-I) LTR, human T cell leukemia virus type-I (HTLV-I) env-pX region
    Research applicationImmunology and Inflammation Research
    Mouse Models for Human Disease
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Science, 253, 1026-1028 (1991).Please obtain the written consent from Professor Yoichiro Iwakura (iwakura@rs.tus.ac.jp; Research Institute for Biological Sciences, Tokyo University of Science) for the use.
    DepositorYoichiro Iwakura (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data