Strain Data Sheet

RBRC04903

Strain Information

Image
BRC No.RBRC04903
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC;129X1-Ifng<tm1Yiw>
Former Common nameC.129X1-Ifng<tm1Yiw>
H-2 Haplotype
ES Cell lineA3-1 [129X1/SvJ]
Background strain
Appearance
Strain developmentDeveloped by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo in 1997. The mice were backcrossed to BALB/c for at least 8 times.
Strain descriptionIFN gamma knockout mice. Homozygous mutant mice show increased susceptibility to infection.
Colony maintenance
References
Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.
Tagawa Y, Sekikawa K, Iwakura Y
J. Immunol., 159, 1418-1428 (1997). 9233639

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ifnginterferon gamma10Ifngtargeted mutation 1, Yoichiro Iwakura
  • aplastic anemia(MedGEN)

  • hepatitis C virus, susceptibility to(MedGEN)

  • immunodeficiency 69(MedGEN)
    • more 3 Diseases
  • mycobacterium tuberculosis, susceptibility to(MedGEN)

  • susceptibility to HIV infection(MedGEN)

  • tuberous sclerosis 2(MedGEN)
    • lacZbeta-galactosidase (E. coli)10
  • aplastic anemia(MedGEN)

  • hepatitis C virus, susceptibility to(MedGEN)

  • immunodeficiency 69(MedGEN)
    • more 3 Diseases
  • mycobacterium tuberculosis, susceptibility to(MedGEN)

  • susceptibility to HIV infection(MedGEN)

  • tuberous sclerosis 2(MedGEN)
    • neoneomycin resistance gene (E. coli)10herpes simplex virus thymidine kinase promoter (HSV tk promoter)
  • aplastic anemia(MedGEN)

  • hepatitis C virus, susceptibility to(MedGEN)

  • immunodeficiency 69(MedGEN)
    • more 3 Diseases
  • mycobacterium tuberculosis, susceptibility to(MedGEN)

  • susceptibility to HIV infection(MedGEN)

  • tuberous sclerosis 2(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal female reproductive system physiology(MP:0003699)

  • decreased apoptosis(MP:0006043)

  • decreased inflammatory response(MP:0001876)

  • hepatic necrosis(MP:0001654)

  • increased susceptibility to infection(MP:0002406)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli lacZ gene, SV40 PolyA signal, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli Neomycin resistance gene, mouse Ifng genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 159, 1418-1428 (1997).Please obtain the written consent from Professor Yoichiro Iwakura (iwakura@rs.tus.ac.jp; Research Institute for Biological Sciences, Tokyo University of Science) for the use. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
    DepositorYoichiro Iwakura (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data