Strain Data Sheet

RBRC04902

update : 2023-09-20

Information1
Image
BRC No.	RBRC04902
Type	Targeted Mutation
Species	Mus musculus
Strain name	B6;129X1-Ifng<tm1Yiw>
Former Common name	B6.129X1-Ifng<tm1Yiw>
H-2 Haplotype
ES Cell line	A3-1 [129X1/SvJ]
Background strain
Appearance
Strain development	Developed by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo in 1997. The mice were backcrossed to C57BL/6 for at least 12 times.
Strain description	IFN gamma knockout mice. Homozygous mutant mice show increased susceptibility to infection.
Colony maintenance
References	J. Immunol., 159, 1418-1428 (1997). 9233639

Health Report
Examination Date / Room / Rack

Gene
Gene info	Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Ifnginterferon gamma10Ifng<tm1Yiw>targeted mutation 1, Yoichiro Iwakura Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)10herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)10

Gene info

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

Ifnginterferon gamma10Ifng<tm1Yiw>targeted mutation 1, Yoichiro Iwakura

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

lacZbeta-galactosidase (E. coli)10herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter

neoneomycin resistance gene (E. coli)10

Information2
Donor DNA	E. coli lacZ gene, SV40 PolyA signal, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli Neomycin resistance gene, mouse Ifng genomic DNA
Research application	Immunology and Inflammation Research
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 159, 1418-1428 (1997).Please obtain the written consent from Professor Yoichiro Iwakura (iwakura@rs.tus.ac.jp; Research Institute for Biological Sciences, Tokyo University of Science) for the use. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Depositor	Yoichiro Iwakura (The University of Tokyo)
Strain Status	Frozen embryos Frozen sperm
Strain Availability	Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month)
Additional Info.	Genotyping protocol -PCR- Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data