Strain Data Sheet

RBRC04896

Strain Information

Image
BRC No.RBRC04896
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6;B6D2-Tg(Col11a2-Ddr2*DN)
Former Common nameB6-Col11a2-Ddr2/DN Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Kiyoshi Kano, Graduate School of Agricultural and Life Science, University of Tokyo in 2010.
Strain description
Colony maintenanceCarrier x Noncarrier [C57BL/6JJmsSlc] Tg mice are viable and fertile.
References
Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice.
Kano K, Kitamura A, Matsuwaki T, Morimatsu M, Naito K
Mol. Reprod. Dev., 77, 29-37 (2010). 19681157

Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene, Ddr2, as a regulator of ovarian function.
Matsumura H, Kano K, Marin de Evsikova C, Young J A, Nishina P M, Naggert J K, Naito K
Physiol. Genomics, 39, 120-129 (2009). 19671659

A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse.
Kano K, Marin de Evsikova C, Young J, Wnek C, Maddatu T P, Nishina P M, Naggert J K
Mol. Endocrinol., 22, 1866-1880 (2008). 18483174

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ddr2discoidin domain receptor family, member 2UNDdr2mouse Col11a2 promoter, intron
  • autosomal dominant nonsyndromic hearing loss 13(DisGeNET, MedGEN)

  • autosomal recessive nonsyndromic hearing loss 53(MedGEN)

  • fibrochondrogenesis 2(MedGEN)
    • more 4 Diseases
  • otospondylomegaepiphyseal dysplasia, autosomal dominant(MedGEN)

  • otospondylomegaepiphyseal dysplasia, autosomal recessive(MedGEN)

  • spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome(MedGEN)

  • warburg-cinotti syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal spermatogonia morphology(MP:0006378)

  • absent Leydig cells(MP:0002785)

  • absent corpus luteum(MP:0001134)

  • absent ovarian follicles(MP:0002777)

  • anovulation(MP:0008869)
    • more 19 phenotypes
  • decreased blood urea nitrogen level(MP:0005566)

  • decreased body fat mass(MP:0014143)

  • decreased body mass index(MP:0006086)

  • decreased bone mineral content(MP:0010124)

  • decreased growth hormone level(MP:0005136)

  • decreased pituitary gland weight(MP:0008938)

  • decreased sterol level(MP:0012225)

  • disproportionate dwarf(MP:0002427)

  • exophthalmos(MP:0002750)

  • growth retardation of incisors(MP:0005359)

  • growth/size/body region phenotype(MP:0005378)

  • hypopituitarism(MP:0003348)

  • increased circulating glucose level(MP:0005559)

  • postnatal lethality(MP:0002082)

  • reduced female fertility(MP:0001923)

  • reduced male fertility(MP:0001922)

  • short snout(MP:0000445)

  • slow postnatal weight gain(MP:0008489)

  • small pituitary gland(MP:0005361)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Col11a2 promoter, intronの一部, Mouse Ddr2 cDNAの一部, SV40 PolyA signal, SV40 Intron, exonの一部
    Research application
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorKiyoshi Kano (The University of Tokyo)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data