Strain Data Sheet

RBRC04889

Strain Information

Image
BRC No.RBRC04889
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameMRL.CB-Fas<lpr-cg>
Former Common nameMRL-lpr<cg>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Akio Matsuzawa, Institute of Medical Science in Tokyo. The mutant mice were baccrossed to MRL for 12 times. Deposited by Kazutoshi Sayama, Faculty of Agriculture, Shizuoka University.
Strain description
Colony maintenanceHomozygote x Homozygote
References
Alleviation of renal disease and lymphadenopathy in MRL-Fasp(lrcg)/Fas(lprcg) (MR-lpr(cg)) mice neonatally infected with mouse mammary tumor virus encoding superantigen strongly reactive with TCR Vbeta8.2 element.
Matsuzawa A, Yasuda T, Zhang Y, Nagase H, Yoshimoto T, Kimura M, Tsubura A
Viral Immunol., 13, 297-311 (2000). 11016595

Nephritogenicity of the lprcg gene on the MRL background.
Kimura M, Ogata Y, Shimada K, Wakabayashi T, Onoda H, Katagiri T, Matsuzawa A
Immunology, 76, 498-504 (1992) . 1526655

Health Report

Examination Date / Room / Rack2024/04/22Room:3-CRack:A
2024/01/22Room:3-CRack:A
2023/10/23Room:3-CRack:A
2023/07/24Room:3-CRack:A
2023/04/24Room:3-CRack:A
2023/01/23Room:3-CRack:A
2022/10/25Room:3-CRack:A

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
FasFas cell surface death receptor19Faslymphoproliferation complementing gld
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal T cell differentiation(MP:0002145)

  • abnormal hypersensitivity reaction(MP:0002148)

  • abnormal lymph organ size(MP:0002221)

  • autoimmune response(MP:0001844)

  • enlarged lymph nodes(MP:0000702)
    • more 10 phenotypes
  • enlarged spleen(MP:0000691)

  • focal hair loss in head/neck region(MP:0013116)

  • increased IgG level(MP:0002493)

  • increased IgM level(MP:0002494)

  • increased anti-nuclear antigen antibody level(MP:0004794)

  • increased autoantibody level(MP:0003725)

  • increased immunoglobulin level(MP:0002461)

  • increased spleen weight(MP:0004952)

  • premature death(MP:0002083)

  • skin inflammation(MP:0004947)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorKazutoshi Sayama (Shizuoka University)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    Strain AvailabilityCryopreserved embryos (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data