Strain Data Sheet

RBRC04865

Strain Information

Image
BRC No.RBRC04865
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB10.B6-Kit<W-sh>/Hir
Former Common nameB10-sh
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tomohisa Hirobe, National Institute of Radiological Sciences in 1990. sash (W<sh>) locus from C57BL/6J- W<sh>/+ (Osaka University) was backcrossed into the C57BL/10JMsHir, and then mantained by sister-brother mating.
Strain descriptionC57BL/10 congenic strain of sash locus from C57BL/6J-W<sh>/+ strain. Black (a/a B/B C/C D/D P/P E/E +/+); black with a white sash (a/a B/B C/C D/D P/P E/E W<sh>/+); white coat with black eyes (a/a B/B C/C D/D P/P E/E W<sh>/W<sh>). Lack of melanocyte of skin.
Colony maintenanceHeterozygote x Heterozygote, Wild-type
References
How are proliferation and differentiation of melanocytes regulated?
Hirobe T
Pigment Cell Melanoma Res., 24(3):462-478 (2011). 21375698

Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture.
Hirobe T, Abe H
Pigment Cell Res., 12, 147-163 (1992). 10385911

Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle.
Hirobe T
Histol Histopathol., 10, 223-237 (1995). 7756740

Control of melanocyte proliferation and differentiation in the mouse epidermis.
Hirobe T
Pigment Cell Res., 5, 1-11 (1992). 1631016

Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes.
Hirobe T
Pigment Cell Res., 18, 2-12 (2005). 15649147

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
KitKIT proto-oncogene receptor tyrosine kinase5Kitsash
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • cutaneous mastocytosis(MedGEN)

  • gastrointestinal stromal tumor(DisGeNET, MedGEN)
    • more 3 Diseases
  • mastocytosis(DisGeNET)

  • piebaldism(DisGeNET, MedGEN)

  • testicular germ cell tumor(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal coat/hair pigmentation(MP:0002075)

  • abnormal definitive hematopoiesis(MP:0002123)

  • abnormal erythrocyte cell number(MP:0001586)

  • abnormal vascular permeability(MP:0001619)

  • absent coat pigmentation(MP:0005171)
    • more 7 phenotypes
  • decreased erythrocyte cell number(MP:0002875)

  • decreased mast cell degranulation(MP:0008765)

  • decreased mast cell number(MP:0000336)

  • decreased susceptibility to type I hypersensitivity reaction(MP:0005597)

  • impaired behavioral response to xenobiotic(MP:0009747)

  • increased susceptibility to parasitic infection(MP:0005027)

  • variable body spotting(MP:0002940)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Pigmnet Cell Melanoma Res., 24(3):462-478 (2011).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTomohisa Hirobe (National Institute of Radiological Sciences (NIRS))
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data