RBRC04860

Information1

Image
BRC No.RBRC04860
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB10.C-Tyr<c>/Hir
Former Common nameB10-c
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tomohisa Hirobe, National Institute of Radiological Sciences in 1986. Albino (c) locus from BALB/cCrJms was backcrossed into the C57BL/10JMsHir, and then mantained by sister-brother mating.
Strain descriptionC57BL/10 congenic strain of albino locus from BALB/c strain. Albino (a/a B/B c/c D/D P/P E/E). No melanocyte in skin and eyes.
Colony maintenanceHomozygote x Homozygote
ReferencesPigment Cell Res., 18, 2-12 (2005). 15649147
Pigment Cell Res., 12, 147-163 (1992). 10385911
Pigment Cell Res., 5, 1-11 (1992). 1631016
Pigment Cell Melanoma Res., 24(3):462-478 (2011). 21375698
Histol Histopathol., 10, 223-237 (1995). 7756740

Health Report

Examination Date / Room / Rack2015/08/03Room:3-3Rack:D
2015/06/01Room:3-3Rack:D
2015/04/06Room:3-3Rack:D
2015/02/02Room:3-3Rack:D
2014/12/01Room:3-3Rack:D
2014/10/06Room:3-3Rack:D
2014/08/04Room:3-3Rack:D
2014/06/02Room:3-3Rack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Tyrtyrosinase7Tyr<c>albino

Information2

Donor DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. T. Hirobe: How are proliferation and differentiation of mouse melanocytes regulated? Pigmnet Cell Melanoma Res., 24(3):462-478 (2011). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DepositorTomohisa Hirobe (National Institute of Radiological Sciences (NIRS))
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

Hamanaka T, Nishizawa K, Sakasegawa Y, Oguma A, Teruya K, Kurahashi H, Hara H, Sakaguchi S, Doh-Ura K.
Melanin or melanin-like substance interacts with the N-terminal portion of prion protein and inhibits abnormal prion protein formation in prion-infected cells.
J. Virol. (2017) 28077650