BRC No.RBRC04841
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6N.129P2-Bhlhe40<tm1Homy>
Former Common nameDec1 KO
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrlCrlj
Strain development
Strain description
Colony maintenance
ReferencesJ. Immunol., 185, 7330-7339 (2010). 21057086

Health Report

Examination Date / Room / Rack2012/03/26Room:4-BRack:C


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Bhlhe40basic helix-loop-helix family member e406Bhlhe40<tm1Homy>targeted mutation 1, Hiroaki Honda

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (Streptomyces fradiase)6herpes simplex virus thymidine kinase promoter (HSV tk promoter)


Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), Streptomyces fradiase neomycin phosphotransferase genomic DNA, mouse Bhlhe40 genomic DNA
Research application
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorHiroaki Honda (Tokyo Women's Medical University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Hu J, Mao Z, He S, Zhan Y, Ning R, Liu W, Yan B, Yang J.
Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3 beta/beta-catenin integrated signaling pathway.
Biochem. Pharmacol. 136 109-121(2017) 28408345