RBRC04834

Information1

Image
BRC No.RBRC04834
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameC57BL/6J-Slc7a11<m1Mtka>
Former Common namexCT mutant
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Masato Tanaka, RIKEN Research Center for Allergy and Immunologuy in 2005. Generated by RIKEN ENU mutagenesis project.
Strain descriptionSlc7a11 mutant mice generated by ENU mutagenesis. A transverstion of G to T in exon 10 was caused and results in a premature termination at position 383 glycine. Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.
Colony maintenanceHeterozygote X Wild-type [C57BL/6JJcl] Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.
ReferencesProc. Natl. Acad. Sci. USA, 107, 6436-6441 (2010). 20308543

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Slc7a11solute carrier family 7 (cationic amino acid transporter, y+ system), member 113Slc7a11<m1Mtka>mutation 1, Masato Tanaka

Information2

Donor DNA
Research applicationCancer Research
Immunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Matl. Acad. Sci., USA, 107, 6436-6441(2010).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. A RECIPIENT shall obtain a prior written approval from the DEPOSITOR using approval form.
DepositorMasato Tanaka (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data