Strain Data Sheet

RBRC04828

Strain Information

Image
BRC No.RBRC04828
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Pold1<tm1.1Uchi>/FTyagRbrc
Former Common nameMutation Accumulation line F
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Arikuni Uchimura and Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University in 2010.
Strain description
Colony maintenance
References
DNA polymerase delta is required for early mammalian embryogenesis.
Uchimura A, Hidaka Y, Hirabayashi T, Hirabayashi M, Yagi T
PLoS One., 4, e4184 (2009). 19145245

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pold1polymerase (DNA directed), delta 1, catalytic subunit7Pold1targeted mutation 1.1, Arikuni Uchimura
  • colorectal cancer, susceptibility to, 10(MedGEN)

  • mandibular hypoplasia-deafness-progeroid syndrome(MedGEN)
    • loxPphage P1 loxP7loxP
  • colorectal cancer, susceptibility to, 10(MedGEN)

  • mandibular hypoplasia-deafness-progeroid syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • embryo phenotype(MP:0005380)

  • enlarged thymus(MP:0000709)

  • increased tumor incidence(MP:0002020)

  • long tail(MP:0002758)

  • premature death(MP:0002083)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Pold1 gene, P1 phage loxP
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. If the RECIPIENT's research results in an invention based on the BIOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR.
    DepositorTakeshi Yagi (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data