Strain Data Sheet

RBRC04827

Strain Information

Image
BRC No.RBRC04827
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Del(18Pcdhb-Pcdhg)/TyagRbrc
Former Common namePcdh b-g KO
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Teruyoshi Hirayama and Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University in 2010.
Strain descriptionHomozygous mutant mice are embryonic lethal.
Colony maintenanceHeterozygote x Wild-type [C57BL/6J(Crlj)]
References
Distinct and Cooperative Functions for the Protocadherin-alpha, -beta and -gamma Clusters in Neuronal Survival and Axon Targeting.
Hasegawa S, Kumagai M, Hagihara M, Nishimaru H, Hirano K, Kaneko R, Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M, Hirabayashi T, Yagi T
Front. Mol. Neurosci., 9:155 (2016). 28066179

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pcdhbprotocadherin beta cluster18Pcdhb
Pcdhgprotocadherin gamma cluster18Pcdhg
loxPphage P1 loxP18loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • embryonic lethality, complete penetrance(MP:0011092)
    • Detailed phenotype data

    Ordering Information

    Donor DNAP1 phage loxP site, mouse Pcdhb genomic DNA, mouse Pcdhg genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. If the RECIPIENT's research results in an invention based on the BIOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR.
    DepositorTakeshi Yagi (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data