Strain Data Sheet

RBRC04821

Strain Information

Image
BRC No.RBRC04821
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameDelta Taf7 Pcdhg
Former Common nameDelta Taf7 Pcdhg
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University in 2010.
Strain descriptionHomozygous mutant mice are embryonic lethal.
Colony maintenanceHeterozygote X Wild-type [C57BL/6J (Crlj)]
References
Distinct and Cooperative Functions for the Protocadherin-alpha, -beta and -gamma Clusters in Neuronal Survival and Axon Targeting.
Hasegawa S, Kumagai M, Hagihara M, Nishimaru H, Hirano K, Kaneko R, Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M, Hirabayashi T, Yagi T
Front. Mol. Neurosci., 9:155 (2016). 28066179

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pcdhgprotocadherin gamma cluster18Pcdhg
Taf7TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor18Taf7
loxPphage P1 loxP18loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal brainstem morphology(MP:0005277)

  • abnormal innervation(MP:0002184)

  • abnormal medulla oblongata morphology(MP:0000846)

  • abnormal olfactory bulb interneuron morphology(MP:0009941)

  • abnormal olfactory bulb morphology(MP:0000819)
    • more 9 phenotypes
  • abnormal postsynaptic density morphology(MP:0020551)

  • abnormal spinal cord ventral commissure morphology(MP:0009695)

  • astrocytosis(MP:0003354)

  • decreased midbrain size(MP:0012089)

  • decreased spinal cord size(MP:0000956)

  • hunched posture(MP:0001505)

  • increased neuron apoptosis(MP:0003203)

  • increased retina apoptosis(MP:0030005)

  • umbilical hernia(MP:0010146)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP site, Mouse Pcdh-g, Taf7
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. If the RECIPIENT's research results in an invention based on the BIOLOGICAL RESOURCE, the RECIPIENT must contact DEPOSITOR to negotiate. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the RECIPIENT must obtain a prior written consent from the DEPOSITOR.
    DepositorTakeshi Yagi (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data