RBRC04813

Information1

Image
BRC No.RBRC04813
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.B6D2-Tg(Eno2-IREB2)1Kiwa
Former Common nameNSE-IRP2 Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Kazuhiro Iwai, Graduate School of Medicine, Osaka City University in 2002.Transgene was injected into the pronuclei of B6D2F1 fertilized eggs. Backcrossed to C57BL/6J.
Strain descriptionThis transgenic mice express a human IRP2 gene under the control of the rat neuron specific enolase promoter. IRP2 gene is a iron regulatory factor. Tg mice exhibit increased intercellular iron in neuron specific cells, and a nerve degeneration and behavior disorders with aging.
Colony maintenanceCarrier X Noncarrier [C57BL/6J (Crlj)]Tg mice show a low activity after around 15 months of age, and a low motor coordination after around 21 months of age.
References

Health Report

Examination Date / Room / Rack2013/01/21Room:4-ARack:J
2012/11/26Room:4-ARack:J
2012/09/24Room:4-ARack:J
2012/07/23Room:4-ARack:J
2012/05/21Room:4-ARack:J
2012/03/26Room:4-ARack:J
2012/01/23Room:4-ARack:J
2011/11/28Room:4-ARack:J

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
IREB2iron responsive element binding protein 2 (human)UNIREB2rat NSE-promoter

Information2

Donor DNARat NSE-promoter, Human irp2, Human myc, Rabbit beta-globin intron, Rabbit 3' LTR
Research applicationNeurobiology Research
Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER. RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or research in non-profit organization is requested to enter into a Material Transfer Agreement with Kyoto University.
DepositorKazuhiro Iwai (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.

BRC mice in Publications

No Data