RBRC04803

Information1

Image
BRC No.RBRC04803
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Bmper<tm2Ysas>/Rbrc
Former Common nameCv2(nlacZ) (Acc.No.CDB0451K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain developmentDeveloped by Dr. Yoshiki Sasai, Center for Developmental Biology, RIKEN.
Strain descriptionThis transgene contains beta-galactosidase with a nuclear localization signal. The first methionine of Cv2 was replaced in-flame with that of lacZ. Cv2 (Bmper : BMP-binding endothelial regulator) is essential for multiple organogenetic processes that involve Bmp signals. Cv2 homozygous mutant mice show effects in the vertebral column and eyes.
Colony maintenanceHeterozygote x Wild-type [C57BL/6] Homozygous mutant mice are neonatal lethal.
ReferencesDevelopment, 133, 4463-4473 (2006). 17035289

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
BmperBMP-binding endothelial regulator9Bmper<tm2Ysas>targeted mutation 2, Yoshiki Sasai

Gene symbolGene nameChr.Allele symbolAllele namePromoter
lacZbeta-galactosidase (E. coli)9

Gene symbolGene nameChr.Allele symbolAllele namePromoter
loxPphage P1 loxP9loxP

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)9

Information2

Donor DNALacZ (大腸菌), polyA (SV40), PGK promoter (mouse) Neo (大腸菌), loxP (P1ファージ)
Research application
Specific Term and Conditions(1) The RECIPIENT shall obtain a prior agreement from Dr. Makoto Ikeya (mikeya@cira.kyoto-u.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0451K, and Web Site (http://www2.clst.riken.jp/arg/mutant%20mice%20list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Development, 133, 4463-4473 (2006).) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
DepositorRIKEN CDB (RIKEN CDB)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.

BRC mice in Publications

No Data