Strain Data Sheet

RBRC04753

Information1

Image
BRC No.RBRC04753
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S4(Cg)-Socs1<tm1Ayos>
Former Common nameSocs1 floxed
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain developmentDeveloped by Akihiko Yoshimura, Medical Institute of Bioregulation, Kyushu University.
Strain descriptionScocs1 floxed mice. A loxP site was inserted downstream of exon 1 and an additional loxP site was inserted in exon 2.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl] Homozygous mice are viable and fertile.
ReferencesJ. Immunol., 180, 3746-3756 (2008). 18322180

Health Report

Examination Date / Room / Rack2021/11/22Room:2-検Rack:C
2021/08/23Room:2-検Rack:C
2021/05/24Room:2-検Rack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Socs1suppressor of cytokine signaling 116Socs1<tm1Ayos>targeted mutation 1, Akihiko YoshimuraCish1, Cish7, JAB, JAK-binding protein, JAK2-binding protein, SOCS-1, SSI-1, STAT-induced STAT inhibitor 1

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP16loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP16loxP

Information2

Donor DNAPhage P1 loxP sites, Mouse Socs1 genomic DNA
Research applicationCre/loxP system
Immunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 180, 3746-3756 (2008). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DepositorAkihiko Yoshimura (Keio University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data