Strain Data Sheet

RBRC04664

Strain Information

Image
BRC No.RBRC04664
TypeTransgeneCartagena
SpeciesMus musculus
Strain name129;FVB-Tg(PDGFB-Ptn)2Rau
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDveloped by Dr. Heikki Rauvala, Institute of Biotechnology and Department of Biosciences, University of Helsinki. PDGF-beta promoter followed by rabbit beta-globulin intron and HB-GAM cDNA and sv40 poly-A-tail. Pavlov et al. (2002), Molecular and Cellular Neuroscience; Vol. 20, pp. 330-342.
Strain descriptionTransgenic mice overexpressing HB-GAM (pleiotrophin). Attenuated long-term potentiation (LTP) in hippocampus. Faster learning in water maze and decreased anxiety in elevated plus-maze compared to the wild-type mice. Pavlov et al. (2002), Molecular and Cellular Neuroscience; Vol. 20, pp. 330-342. Tg mice are viable and no anatomical abnormalities are detected.
Colony maintenanceCarrier x Carrier
References
Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice.
Pavlov I, Voikar V, Kaksonen M, Lauri S E, Hienola A, Taira T, Rauvala H
Mol. Cell. Neurosci., 20, 330-342 (2002). 12093164

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ptnpleiotrophin (rat)UNPtnhuman PDGF-beta promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal spatial reference memory(MP:0008414)

  • decreased anxiety-related response(MP:0001364)
    • Detailed phenotype data

    Ordering Information

    Donor DNAHuman PDGF-beta promoter, Rabiit beta-globin intron, Rat HB-GAM (pleitroghin) cDNA, SV40 polyadenylation signal
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested. Mol. Cell Neurosci., 2002 20(2):330-242. A recipient shall acquire a prior consent from the DEPOSITOR for the use of the mice.
    DepositorHeikki Rauvala (University of Helsinki)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data