Strain Data Sheet

RBRC04609

Strain Information

Image
BRC No.RBRC04609
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Wnt5a<tm1.1Homy>
Former Common nameWnt5a-floxed
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Hiroaki Honda, Research Institute for Radiation Biology and Medicine, Hiroshima University in 2008.
Strain description
Colony maintenance
References
The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma in colitis.
Sato A, Kayama H, Shojima K, Matsumoto S, Koyama H, Minami Y, Nojima S, Morii E, Honda H, Takeda K, Kikuchi A
Sci. Rep., 5, 10536 (2015). 26030277

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frtyeast FRT (flippase recombination target) site14Frt
  • autosomal dominant Robinow syndrome 1(MedGEN)

  • Robinow syndrome(DisGeNET)
    • Wnt5awingless-type MMTV integration site family, member 5A14Wnt5atargeted mutation 1.1, Homy
  • autosomal dominant Robinow syndrome 1(MedGEN)

  • Robinow syndrome(DisGeNET)
    • loxPphage P1 loxP14loxP
  • autosomal dominant Robinow syndrome 1(MedGEN)

  • Robinow syndrome(DisGeNET)
    • loxPphage P1 loxP14loxP
  • autosomal dominant Robinow syndrome 1(MedGEN)

  • Robinow syndrome(DisGeNET)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, yeast FRT (flippase recombination target) site, mouse Wnt5a genomic DNA
    Research applicationCre/loxP system
    Developmental Biology Research
    FLP/frt system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorHiroaki Honda (Tokyo Women's Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, Hayashi K, Honda H, Kikuchi A, Price C, Boerboom D.
    WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
    FASEB J 30(4) 1534-47(2016) 26667040