Strain Data Sheet

RBRC04607

Strain Information

Image
BRC No.RBRC04607
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Ciz1<tm1.1Homy>
Former Common nameCiz1 knockout
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Hiroaki Honda, Research Institute for Radiation Biology and Medicine, Hiroshima University in 2008.
Strain description
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ciz1CDKN1A interacting zinc finger protein 12Ciz1targeted mutation 1.1, Hiroaki Honda
Frtyeast FRT (flippase recombination target) site2Frt
Frtyeast FRT (flippase recombination target) site2Frt
loxPphage P1 loxP2loxP
neoneomycin resistance gene (E. coli)2

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • cellular phenotype(MP:0005384)

  • embryo phenotype(MP:0005380)

  • enlarged spleen(MP:0000691)

  • growth/size/body region phenotype(MP:0005378)

  • increased cellular sensitivity to hydroxyurea(MP:0008409)
    • more 3 phenotypes
  • increased tumor incidence following infection(MP:0012563)

  • lymph node hyperplasia(MP:0008102)

  • thymus hyperplasia(MP:0000708)
    • Detailed phenotype data

    Ordering Information

    Donor DNACiz1 (マウス), LoxP (ファージ), FRT (出芽酵母), ネオマイシン耐性遺伝子 (クレブシエラ・ニューモニエ (バクテリアトランスポゾンTn5))
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorHiroaki Honda (Tokyo Women's Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data