Strain Data Sheet

RBRC04546

Strain Information

Image
BRC No.RBRC04546
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129B6-Mavs<tm1Tsse>
Former Common nameIPS-1 (MAVS/VISA/Cardif) KO
H-2 Haplotype
ES Cell lineEGR-G01 [129S2 x C57BL/6NCr-Tg(CAG/Acr-EGFP)]
Background strain
Appearance
Strain developmentDeveloped by Hiroyuki Oshiumi, Graduate School of Medicine, Hokkaido University in 2009.
Strain description
Colony maintenance
References
The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.
Oshiumi H, Okamoto M, Fujii K, Kawanishi T, Matsumoto M, Koike S, Seya T
J. Immunol., 187 (10) 5320-7 (2011). 21998457

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mavs
MGI:2444773		mitochondrial antiviral signaling protein2Mavs<tm1Tsse> targeted mutation 1, Tsukasa Seya
neo neomycin resistance gene (E. coli)2 mouse Phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • normal phenotype (MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Phosphoglycerate kinase promoter (PGK promoter), E.coli Neomycin resistance gene, mouse mavs genomic DNA
    Research applicationImmunology and Inflammation Research
    covid19_onset
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorTsukasa Seya (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Sato H, Hoshi M, Ikeda F, Fujiyuki T, Yoneda M, Kai C.
    Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase.
    PLoS Pathog 17(10) e1009841(2021) 34648591