Strain Data Sheet

RBRC04546

Information1

Image
BRC No.RBRC04546
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129B6-Mavs<tm1Tsse>
Former Common nameIPS-1 (MAVS/VISA/Cardif) KO
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Hiroyuki Oshiumi, Graduate School of Medicine, Hokkaido University in 2009.
Strain description
Colony maintenance
ReferencesJ. Immunol., 187 (10) 5320-7 (2011). 21998457

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Mavsmitochondrial antiviral signaling protein2Mavs<tm1Tsse>targeted mutation 1, Tsukasa Seya

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)2mouse Phosphoglycerate kinase promoter (PGK promoter)

Information2

Donor DNAmouse Phosphoglycerate kinase promoter (PGK promoter), E.coli Neomycin resistance gene, mouse mavs genomic DNA
Research applicationImmunology and Inflammation Research
covid19_onset
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorTsukasa Seya (Hokkaido University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-
Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

Sato H, Hoshi M, Ikeda F, Fujiyuki T, Yoneda M, Kai C.
Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase.
PLoS Pathog 17(10) e1009841(2021) 34648591