Strain Data Sheet


Strain Information

BRC No.RBRC04546
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129B6-Mavs<tm1Tsse>
Former Common nameIPS-1 (MAVS/VISA/Cardif) KO
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Hiroyuki Oshiumi, Graduate School of Medicine, Hokkaido University in 2009.
Strain description
Colony maintenance
ReferencesJ. Immunol., 187 (10) 5320-7 (2011). 21998457

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Mavsmitochondrial antiviral signaling protein2Mavs<tm1Tsse>targeted mutation 1, Tsukasa Seya

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)2mouse Phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

Donor DNAmouse Phosphoglycerate kinase promoter (PGK promoter), E.coli Neomycin resistance gene, mouse mavs genomic DNA
Research applicationImmunology and Inflammation Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorTsukasa Seya (Hokkaido University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Sato H, Hoshi M, Ikeda F, Fujiyuki T, Yoneda M, Kai C.
Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase.
PLoS Pathog 17(10) e1009841(2021) 34648591