Strain Data Sheet


Strain Information

BRC No.RBRC04495
SpeciesMus musculus
Strain nameB6.Cg-Tg(Tek-cre)1Ywa
Former Common nameTie2-Cre, B6-TekCre Tg
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. Mixed background.
Strain descriptionTek-cre (Tie2-cre) transgenic mice. These mice express a cre recombinase gene under the control of the mouse Tek promoter.
Colony maintenanceCarrier x Noncarrier [or Crossing to C57BL/6N(Crlj)]
ReferencesJ. Clin. Invest., 108, 537-546 (2001). 11518727
Dev. Biol., 230, 230-242 (2001). 11161575

Health Report

Examination Date / Room / Rack2024/04/08Room:3-ARack:G


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Mt1mouse metallothionein-1(MT-1) polyA signalUNMt1

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
crePhage P1 Cre recombinaseUNcretransgene insertion 1, Masashi Yanagisawamouse endothelial-specific receptor tyrosine kinase promoter

Ordering Information

Donor DNAmouse Tie2 promoter, Phage P1 Cre, mouse metallothionein-1(MT-1) poly A signal, mouse Tie2 intron 1 enhancer
Research applicationCre/loxP system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 230, 230-242 (2001). Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE.
DepositorMasashi Yanagisawa (University of Texas Southwestern Medical Center at Dallas)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (1 to 3 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP
Genotyping protocol -PCR-

BRC mice in Publications

Arai HN, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, Sehara-Fujisawa A.
Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate.
Cell Rep 29(3) 603-616.e5(2019) 31618630

Sawaguchi S, Varshney S, Ogawa M, Sakaidani Y, Yagi H, Takeshita K, Murohara T, Kato K, Sundaram S, Stanley P, Okajima T.
O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals.
Elife 6 (2017) 28395734

Lee J, Lee H, Lee H, Shin M, Shin MG, Seo J, Lee EJ, Park SA, Park S.
ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.
Nat Commun 14(1) 8463(2023) 38123547

Kakae M, Nakajima H, Tobori S, Kawashita A, Miyanohara J, Morishima M, Nagayasu K, Nakagawa T, Shigetomi E, Koizumi S, Mori Y, Kaneko S, Shirakawa H.
The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production.
Sci Adv 9(29) eadh0102(2023) 37478173