Strain Data Sheet
RBRC04395
Information1 | |
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| Image | |
| BRC No. | RBRC04395 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6;129-Siglec1<tm1(HBEGF)Mtka> |
| Former Common name | CD169-DTR KO |
| H-2 Haplotype | |
| ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
| Background strain | |
| Appearance | |
| Strain development | Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunology. R1 ES cells were used. C57BL/6 background. |
| Strain description | CD169 (Siglec1) DTR knock-in mice. HB-EGF is expressed from CD169 locus. |
| Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6JJcl] |
| References | J. Clin. Invest., 117, 2268-2278 (2007). 17657313 Nat. Biotechnol., 19, 746-750 (2001). 11479567 |
Health Report | |
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| Examination Date / Room / Rack | 2022/06/13Room:3-2Rack:B 2022/03/14Room:3-2Rack:B 2021/12/14Room:3-2Rack:B 2021/10/11Room:3-2Rack:B 2021/10/11Room:3-2Rack:B 2021/09/13Room:3-2Rack:B 2021/06/14Room:3-2Rack:B 2021/03/29Room:3-2Rack:B 2021/03/22Room:3-2Rack:B 2021/03/15Room:3-2Rack:B 2021/01/25Room:3-2Rack:B 2021/01/05Room:3-2Rack:B 2020/10/05Room:3-2Rack:B |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin2Siglec1<tm1(HBEGF)Mtka>targeted mutation 1, Masato Tanaka Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HBEGFheparin-binding EGF-like growth factor (human)2HBEGF Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP2loxP |
Information2 | |
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| Donor DNA | Human HB-EGF(DTR) cDNA, Phage P1 loxP site, Mouse Siglec1 genomic DNA |
| Research application | Cre/loxP system Immunology and Inflammation Research |
| Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Biotechnol., 19, 746-750 (2001). J. Clin Invest., 117, 2268-2278 (2007).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR/DEVELOPER (Masato Tanaka, Ph.D. and Kenji Kohno, Ph.D.) is requested. |
| Depositor | Masato Tanaka (RIKEN) |
| Strain Status |  Live mice Frozen embryos Frozen sperm |
| Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (3 to 6 months) |
| Additional Info. | Mouse of the Month Dec 2012 Genetic Background Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Chalot M, Barroca V, Devanand S, Hoffschir F, Roméo PH, Moreno SG. Deleterious effect of bone marrow-resident macrophages on hematopoietic stem cells in response to total body irradiation. Blood Adv (2022) 35100346 Wang D, Li Q, Yang Y, Hao S, Han X, Song J, Yin Y, Li X, Tanaka M, Qiu CH. Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22. Inflammation 40(4) 1191-1203(2017) 28466432 Jing W, Guo X, Wang G, Bi Y, Han L, Zhu Q, Qiu C, Tanaka M, Zhao Y. Breast cancer cells promote CD169+ macrophage-associated immunosuppression through JAK2-mediated PD-L1 upregulation on macrophages. Int Immunopharmacol 78 106012(2020) 31865052 Jing W, Qin F, Guo X, Sun Y, Yan C, Qiu C, Tanaka M, Shi B, Zhao Y. G-CSF mediates lung injury in mice with adenine-induced acute kidney injury. Int Immunopharmacol 63 1-8(2018) 30056257 Zhang J, Supakorndej T, Krambs JR, Rao M, Abou-Ezzi G, Ye RY, Li S, Trinkaus K, Link DC. Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking. J Clin Invest 129(7) 2920-2931(2019) 31039135 Pirgova G, Chauveau A, MacLean AJ, Cyster JG, Arnon TI. Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal center B cells in the spleen. Proc Natl Acad Sci U S A 117(22) 12295-12305(2020) 32424104 |