Strain Data Sheet

RBRC04198

Information1

Image
BRC No.RBRC04198
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Cxcr4<tm2Tng>
Former Common nameCXCR4 flox
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Takashi Nagasawa, Resrarch institute, Osaka Medical Center for Maternal and Child Health.
Strain description
Colony maintenance
ReferencesImmunity, 20, 707-718 (2004). 15189736

Health Report

Examination Date / Room / Rack2020/11/16Room:3-CRack:D
2020/08/24Room:3-CRack:D

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Cxcr4chemokine (C-X-C motif) receptor 41Cxcr4<tm2Tng>targeted mutation 2, Takashi Nagasawa

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP1loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP1loxP

Information2

Donor DNAPhage P1 loxP sites, Mouse Cxcr4 genomic DNA
Research applicationCre/loxP system
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT is requested to make a Material Transfer Agreement with the DEPOSITOR. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent form the DEPOSITOR.
DepositorTakashi Nagasawa (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Mouse of the Month Dec 2014
Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Kurita K, Ishikawa K, Takeda K, Fujimoto M, Ono H, Kumagai J, Inoue H, Yokoh H, Yokote K.
CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet.
Sci Rep 9(1) 6165(2019) 30992469