Strain Data Sheet

RBRC04065

Strain Information

Image
BRC No.RBRC04065
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(Myh6-CTGF)13Aram
Former Common nameCTGF cardiac specific Tg mouse
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearance
Strain developmentDeveloped by Masashi Arai, Gunma University Graduate School of Medicine in 2006.
Strain description
Colony maintenance
References
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.
Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, Kurabayashi M
Eur. J. Heart. Fail., 10, 373-379 (2008). 18337169

Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis.
Koitabashi N, Arai M, Kogure S, Niwano K, Watanabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takigawa M, Kurabayashi M
Hypertension, 49, 1120-1127 (2007). 17372041

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
SV40 polyA signalUN
  • atrial septal defect 3(MedGEN)

  • dilated cardiomyopathy 1EE(DisGeNET, MedGEN)

  • hypertrophic cardiomyopathy 14(DisGeNET, MedGEN)
    • more 2 Diseases
  • hypertrophic cardiomyopathy 1(MedGEN)

  • sick sinus syndrome 3, susceptibility to(MedGEN)
    • CTGFconnective tissue growth factor (human)UNCTGFmouse alpha-myocin heavy chain promoter
  • atrial septal defect 3(MedGEN)

  • dilated cardiomyopathy 1EE(DisGeNET, MedGEN)

  • hypertrophic cardiomyopathy 14(DisGeNET, MedGEN)
    • more 2 Diseases
  • hypertrophic cardiomyopathy 1(MedGEN)

  • sick sinus syndrome 3, susceptibility to(MedGEN)
    • myc-tagmyc-epitope tagUNmyc-tag
  • atrial septal defect 3(MedGEN)

  • dilated cardiomyopathy 1EE(DisGeNET, MedGEN)

  • hypertrophic cardiomyopathy 14(DisGeNET, MedGEN)
    • more 2 Diseases
  • hypertrophic cardiomyopathy 1(MedGEN)

  • sick sinus syndrome 3, susceptibility to(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse alpha-myocin heavy chain promoter, (tag) Myc tag, Human CTGF gene cDNA, SV40 PolyA signal
    Research applicationCardiovascular Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorMasashi Arai (Gunma University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data