Strain Data Sheet

RBRC04063

Strain Information

Image
BRC No.RBRC04063
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129S6/SvEvTac-Cadm1<tm1Momo>
Former Common nameRa175-KO mouse
H-2 Haplotype
ES Cell line
Background strain129S6/SvEvTac
Appearance
Strain developmentDeveloped by Mariko Momoi, Jichi Medical School and Takashi Momoi, National Institute of Neuroscience.
Strain descriptionHomozygous mutant males are infertile.
Colony maintenance
References
Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily.
Fujita E, Kouroku Y, Ozeki S, Tanabe Y, Toyama Y, Maekawa M, Kojima N, Senoo H, Toshimori K, Momoi T
Mol. Cell Biol., 26, 718-726 (2006). 16382161

Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice.
Fujita E, Tanabe Y, Hirose T, Aurrand-Lions M, Kasahara T, Imhof B A, Ohno S, Momoi T
Am. J. Pathol., 171, 1800-1810 (2007). 18055550

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cadm1cell adhesion molecule 19Cadm1targeted mutation 1, Takashi Momoi
lacZbeta-galactosidase (E. coli)9mouse phosphoglycerate kinase promoter (PGK promoter)
neoneomycin resistance gene (E. coli)9

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal spermatid morphology(MP:0006380)

  • abnormal testis weight(MP:0004850)

  • arrest of spermiogenesis(MP:0008279)

  • asthenozoospermia(MP:0002675)

  • decreased male germ cell number(MP:0004901)
    • more 3 phenotypes
  • male infertility(MP:0001925)

  • oligozoospermia(MP:0002687)

  • teratozoospermia(MP:0005578)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Phosphoglycerate kinase promoter (PGK promoter), E. coli lacZ (Beta-galactosidase), E. coli neo (Neomycin resistance gene), mouse Cadm1 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 未定Within a period of two years after deposition of the BIOLOGICAL RESOURCE, the RECIPIENT shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR and notify him/her a content of the research. If the DEPOSITOR judges that the research should be a collaborative work, then the RECIPIENT must include the DEPOSITOR and/or the DEVELOPER's names as co-authors.
    DepositorTakashi Momoi (National Center of Neurology and Psychiatry/ Jichi Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data