Strain Data Sheet

RBRC04062

Strain Information

Image
BRC No.RBRC04062
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S6-Cadm1<tm1Momo>
Former Common nameRa175-KO mouse
H-2 Haplotype
ES Cell line
Background strain129
Appearance
Strain developmentDeveloped by Takashi Momoi, National Institute of Neuroscience.
Strain description
Colony maintenance
References
Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice.
Fujita E, Tanabe Y, Hirose T, Aurrand-Lions M, Kasahara T, Imhof B A, Ohno S, Momoi T
Am. J. Pathol., 171, 1800-1810 (2007). 18055550

Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily.
Fujita E, Kouroku Y, Ozeki S, Tanabe Y, Toyama Y, Maekawa M, Kojima N, Senoo H, Toshimori K, Momoi T
Mol. Cell Biol., 26, 718-726 (2006). 16382161

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cadm1cell adhesion molecule 19Cadm1targeted mutation 1, Takashi Momoi
lacZbeta-galactosidase (E. coli)9mouse phosphoglycerate kinase promoter (PGK promoter)
neoneomycin resistance gene (E. coli)9

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal GABAergic neuron morphology(MP:0003245)

  • abnormal bone trabecular spacing(MP:0013629)

  • abnormal excitatory postsynaptic potential(MP:0002912)

  • abnormal excitatory synapse morphology(MP:0020357)

  • abnormal fear/anxiety-related behavior(MP:0002065)
    • more 23 phenotypes
  • abnormal gait(MP:0001406)

  • abnormal hippocampus CA3 region morphology(MP:0008267)

  • abnormal hippocampus pyramidal cell morphology(MP:0009940)

  • abnormal hippocampus stratum radiatum morphology(MP:0011151)

  • abnormal long-term depression(MP:0001898)

  • abnormal motor coordination/balance(MP:0001516)

  • abnormal postsynaptic density morphology(MP:0020551)

  • abnormal response to social novelty(MP:0020395)

  • abnormal social recognition(MP:0020396)

  • abnormal spatial learning(MP:0001463)

  • abnormal spermatid morphology(MP:0006380)

  • abnormal testis weight(MP:0004850)

  • arrest of spermiogenesis(MP:0008279)

  • asthenozoospermia(MP:0002675)

  • decreased bone mass(MP:0004016)

  • decreased bone volume(MP:0010876)

  • decreased male germ cell number(MP:0004901)

  • increased bone resorption(MP:0004992)

  • male infertility(MP:0001925)

  • nervous system phenotype(MP:0003631)

  • oligozoospermia(MP:0002687)

  • slow extinction of fear memory(MP:0012318)

  • teratozoospermia(MP:0005578)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Phosphoglycerate kinase promoter (PGK promoter), E. coli lacZ (Beta-galactosidase), E. coli neo (Neomycin resistance gene), mouse Cadm1 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 未定Within a period of three years after deposition of the BIOLOGICAL RESOURCE, the RECIPIENT shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR and notify him/her a content of the research. If the DEPOSITOR judges that the research should be a collaborative work, then the RECIPIENT must include the DEPOSITOR and/or the DEVELOPER's names as co-authors.
    DepositorTakashi Momoi (National Center of Neurology and Psychiatry/ Jichi Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data