Strain Data Sheet

RBRC04062

Strain Information

Image
BRC No.RBRC04062
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S6-Cadm1<tm1Momo>
Former Common nameRa175-KO mouse
H-2 Haplotype
ES Cell line
Background strain129
Appearance
Strain developmentDeveloped by Takashi Momoi, National Institute of Neuroscience.
Strain description
Colony maintenance
References
Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily.
Eriko Fujita, Yoriko Kouroku, Satomi Ozeki, Yuko Tanabe, Yoshiro Toyama, Mamiko Maekawa, Naosuke Kojima, Haruki Senoo, Kiyotaka Toshimori, Takashi Momoi
Mol. Cell Biol., 26, 718-726 (2006). 16382161

Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice.
Eriko Fujita, Yuko Tanabe, Tomonori Hirose, Michel Aurrand-Lions, Tadashi Kasahara, Beat A Imhof, Shigeo Ohno, Takashi Momoi
Am. J. Pathol., 171, 1800-1810 (2007). 18055550

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cadm1
MGI:1889272		cell adhesion molecule 19Cadm1<tm1Momo>
MGI:3769418		targeted mutation 1, Takashi Momoi
lacZ beta-galactosidase (E. coli)9 mouse phosphoglycerate kinase promoter (PGK promoter)
neo neomycin resistance gene (E. coli)9

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal GABAergic neuron morphology (MP:0003245)

  • abnormal bone trabecular spacing (MP:0013629)

  • abnormal excitatory postsynaptic potential (MP:0002912)

  • abnormal excitatory synapse morphology (MP:0020357)

  • abnormal fear/anxiety-related behavior (MP:0002065)
    • more 22 phenotypes
  • abnormal gait (MP:0001406)

  • abnormal hippocampus CA3 region morphology (MP:0008267)

  • abnormal hippocampus pyramidal cell morphology (MP:0009940)

  • abnormal hippocampus stratum radiatum morphology (MP:0011151)

  • abnormal long-term depression (MP:0001898)

  • abnormal motor coordination/balance (MP:0001516)

  • abnormal postsynaptic density morphology (MP:0020551)

  • abnormal response to social novelty (MP:0020395)

  • abnormal social recognition (MP:0020396)

  • abnormal spatial learning (MP:0001463)

  • abnormal spermatid morphology (MP:0006380)

  • abnormal testis weight (MP:0004850)

  • arrest of spermiogenesis (MP:0008279)

  • asthenozoospermia (MP:0002675)

  • decreased bone mass (MP:0004016)

  • decreased bone volume (MP:0010876)

  • decreased male germ cell number (MP:0004901)

  • increased bone resorption (MP:0004992)

  • male infertility (MP:0001925)

  • oligozoospermia (MP:0002687)

  • slow extinction of fear memory (MP:0012318)

  • teratozoospermia (MP:0005578)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Phosphoglycerate kinase promoter (PGK promoter), E. coli lacZ (Beta-galactosidase), E. coli neo (Neomycin resistance gene), mouse Cadm1 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 未定Within a period of three years after deposition of the BIOLOGICAL RESOURCE, the RECIPIENT shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR and notify him/her a content of the research. If the DEPOSITOR judges that the research should be a collaborative work, then the RECIPIENT must include the DEPOSITOR and/or the DEVELOPER's names as co-authors.
    DepositorTakashi Momoi (National Center of Neurology and Psychiatry/ Jichi Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data