Strain Data Sheet


Strain Information

BRC No.RBRC03987
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Ep400<tm3Fuku>
Former Common namemDomEx15-flox
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strainC57BL/6
Strain developmentDeveloped by Rikiro Fukubnaga, Kyoto University in 2008.
Strain description
Colony maintenance
ReferencesJ. Biol. Chem., 285(39):30214-30223(2010). 20610385
Genes Cells, 12, 581-592 (2007). 17535249

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ep400E1A binding protein p4005Ep400<tm3Fuku>targeted mutation 3, Rikiro Fukunaga

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP5loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP5loxP

Ordering Information

Donor DNAphage P1 loxP sites, mouse Ep400 genomic DNA
Research applicationCell Biology Research
Cre/loxP system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 285(39):30214-30223(2010). RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose. The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. For period of two (2) years after deposition by the DEPOSITOR to the REKEN BRC, the RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author.
DepositorRikiro Fukunaga (Kyoto University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Contact Information (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Fujii T, Ueda T, Nagata S, Fukunaga R.
Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression.
J Biol Chem 285(39) 30214-23(2010) 20610385

Fröb F, Sock E, Tamm ER, Saur AL, Hillgärtner S, Williams TJ, Fujii T, Fukunaga R, Wegner M.
Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.
Nat Commun 10(1) 2361(2019) 31142747

Elsesser O, Fröb F, Küspert M, Tamm ER, Fujii T, Fukunaga R, Wegner M.
Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system.
Nucleic Acids Res 47(12) 6208-6224(2019) 31081019