Strain Data Sheet


Strain Information

BRC No.RBRC03950
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Psmb8<tm1Hjf>
Former Common nameLMP7 KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strainC57BL/6
Strain developmentDeveloped by Hans J. Fehling, Basel Institute for Immunology in 1995.
Strain description
Colony maintenance
ReferencesScience, 265, 1234-1237 (1994). 8066463

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)17Psmb8<tm1Hjf>targeted mutation 1, Hans Jorg Fehling

Ordering Information

Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli Neomycin resistance gene, hsv tk polyA signal, mouse LMP7 gene cDNA
Research applicationCell Biology Research
Immunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
DepositorHajime Hisaeda (Kyushu University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

Tomaru U, Konno S, Miyajima S, Kimoto R, Onodera M, Kiuchi S, Murata S, Ishizu A, Kasahara M.
Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells.
Cell Rep 26(3) 639-651.e2(2019) 30650357