RBRC03661

Information1

Image
BRC No.RBRC03661
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Arx<tm(P355L)Kki>/1Rbrc
Former Common nameArx P355L-1 KI (B6)
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeveloped by Dr. Kunio Kitamura, Mistubishi Kagaku Insitute of Life Sciences.
Strain descriptionArx P355L variant knock-in mice
Colony maintenanceHeterozygote x Wild-type [C57BL/6J]
ReferencesHum. Mol. Genet., 18, 3708-3724 (2009). 19605412

Health Report

Examination Date / Room / Rack2011/05/23Room:4-ARack:J
2011/03/22Room:4-ARack:J
2011/01/17Room:4-ARack:J
2010/12/15Room:4-ARack:J
2010/12/14Room:4-ARack:J
2010/12/13Room:4-ARack:J
2010/11/16Room:4-ARack:J
2010/09/13Room:4-ARack:J

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Arxaristaless related homeoboxXArx<tm3Kkitm3Kki>targeted mutation 3, Kunio Kitamura

Information2

Donor DNAARX genomic DNA (mouse), Neomycin resistance gene (E. coli), MC1 promoter (HSV-tk)、PolyA signal (SV40)
Research application
Specific Term and ConditionsThe BIOLOGICAL RESOURCE shall be used only for academic research purposes by
a non-profit organization.
The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and
negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL
RESOURCE for purposes of other than academic research.
In publishing the research results to be obtained by use of the BIOLOGICAL
RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the
source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi
Chemical Corporation.
The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical
Corporation of RECIPIENT organization, RECIPIENT name, the specific research
purpose and the date of distribution.
DepositorKunio Kitamura (Mitsubishi Kasei Institute of Life Sciences)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Xu S, Hayashi Y, Takagishi Y, Itoh M, Murata Y.
Aristaless-Related Homeobox Plays a Key Role in Hyperplasia of the Pancreas Islet alpha-Like Cells in Mice Deficient in Proglucagon-Derived Peptides.
PLoS ONE 8(5) e64415(2013) 23671715