RBRC03653

Information1

Image
BRC No.RBRC03653
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Arx<tm(Dp)Kki>/Rbrc
Former Common nameArx Dp-7 KI (B6), Arx (GCG)dup KI (B6)
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References

Health Report

Examination Date / Room / Rack2012/01/23Room:4-ARack:J
2011/11/28Room:4-ARack:J
2011/09/26Room:4-ARack:J
2011/07/25Room:4-ARack:J
2011/05/23Room:4-ARack:J

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Arxaristaless related homeoboxXArx<tm(Dp)Kki>targeted mutation (Dp), Kunio Kitamura

Information2

Donor DNAmouse Arx genomic DNA, E. coli neo, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
Research application
Specific Term and ConditionsThe BIOLOGICAL RESOURCE shall be used only for academic research purposes by a non-profit organization.
The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL RESOURCE for purposes of other than academic research.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi Chemical Corporation.
The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical Corporation of RECIPIENT organization, RECIPIENT name, the specific research purpose and the date of distribution.
DepositorKunio Kitamura (Mitsubishi Kasei Institute of Life Sciences)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

Lee K, Mattiske T, Kitamura K, Gecz J, Shoubridge C.
Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation.
Hum. Mol. Genet. (2013) 24122442