Strain Data Sheet

RBRC03557

Strain Information

Image
BRC No.RBRC03557
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6C3.129P2-Myog<tm1Yin>
Former Common nameMyog KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Yo-ichi Nabeshima, National Institute of Neuroscience. E14 ES cells were used. C57BL/6 and C3H mixed background.
Strain descriptionMyog (myogenin gene knockout mice. Homozygous mutant mice are embryonic lethal.
Colony maintenanceHeterozygote x Wild-type [or Crossing to Jcl:B6C3F1]
References
Myogenin gene disruption results in perinatal lethality because of severe muscle defect.
Nabeshima Y, Hanaoka K, Hayasaka M, Esumi E, Li S, Nonaka I, Nabeshima Y
Nature, 364, 532-535 (1993). 8393146

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Myogmyogenin1Myogtargeted mutation 1, Yo-ichi Nabeshima
neoneomycin resistance gene (E. coli)1herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • muscle hypoplasia(MP:0000734)

  • neonatal lethality, complete penetrance(MP:0011087)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse myogenin genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 364, 643, 532-535 (1993).
    DepositorNaohiro Hashimoto (National Center for Geriatrics and Gerontology)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data