Strain Data Sheet

RBRC03481

Strain Information

Image
BRC No.RBRC03481
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Chek2<tm1Nmt>
Former Common nameChk2 KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.
Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, Anderson C W, Appella E, Nakanishi M, Suzuki H, Nagashima K, Sawa H, Ikeda K, Motoyama N
EMBO J., 21, 5195-5205 (2002). 12356735

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Chek2checkpoint kinase 25Chek2targeted mutation 1, Noboru Motoyama
  • bone osteosarcoma(MedGEN)

  • colorectal cancer(MedGEN)

  • hereditary breast carcinoma(MedGEN)
    • more 2 Diseases
  • obsolete Li-Fraumeni syndrome 2(MedGEN)

  • prostate cancer(DisGeNET, MedGEN)
    • loxPphage P1 loxP5loxP
  • bone osteosarcoma(MedGEN)

  • colorectal cancer(MedGEN)

  • hereditary breast carcinoma(MedGEN)
    • more 2 Diseases
  • obsolete Li-Fraumeni syndrome 2(MedGEN)

  • prostate cancer(DisGeNET, MedGEN)
    • loxPphage P1 loxP5loxP
  • bone osteosarcoma(MedGEN)

  • colorectal cancer(MedGEN)

  • hereditary breast carcinoma(MedGEN)
    • more 2 Diseases
  • obsolete Li-Fraumeni syndrome 2(MedGEN)

  • prostate cancer(DisGeNET, MedGEN)
    • neoneomycin resistance gene (E. coli)5
  • bone osteosarcoma(MedGEN)

  • colorectal cancer(MedGEN)

  • hereditary breast carcinoma(MedGEN)
    • more 2 Diseases
  • obsolete Li-Fraumeni syndrome 2(MedGEN)

  • prostate cancer(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • decreased cellular sensitivity to ionizing radiation(MP:0004228)

  • decreased mortality induced by ionizing radiation(MP:0003010)
    • Detailed phenotype data

    Ordering Information

    Donor DNABacteriophage loxP sites, Mouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, Mouse Phosphoglycerate kinase PolyA signal, mouse Chek2 genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 21,5195-5205 (2002).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorNoboru Motoyama (National Center for Geriatrics and Gerontology)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data