Strain Data Sheet

RBRC03344

Strain Information

Image
BRC No.RBRC03344
TypeGene TrapCartagena
SpeciesMus musculus
Strain namegoku GT
Former Common namegoku GT
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method.
Osada T, Ikegami S, Takiguchi-Hayashi K, Yamazaki Y, Katoh-Fukui Y, Higashinakagawa T, Sakaki Y, Takeuchi T
J. Neurosci., 19(14): 6068-78 (1999). 10407043

Health Report

Examination Date / Room / Rack2024/05/27Room:4-BRack:L
2024/02/26Room:4-BRack:L
2023/11/27Room:4-BRack:L
2023/09/28Room:4-BRack:L
2023/08/28Room:4-BRack:L

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Iresinternal ribosomal entry site (EMCV)11
Npeppsaminopeptidase puromycin sensitive11Npepps
Zfp40a splicing acceptor site of the mouse zinc-finger gene Zfp 4011Zfp40
lacZbeta-galactosidase (E. coli)11
neoneomycin resistance gene (E. coli)11

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal Sertoli cell morphology(MP:0002784)

  • abnormal seminiferous tubule morphology(MP:0002216)

  • abnormal spermatid morphology(MP:0006380)

  • abnormal spermatogenesis(MP:0001156)

  • asthenozoospermia(MP:0002675)
    • more 12 phenotypes
  • decreased circulating follicle stimulating hormone level(MP:0002790)

  • decreased circulating luteinizing hormone level(MP:0002773)

  • decreased circulating prolactin level(MP:0005121)

  • decreased circulating testosterone level(MP:0002780)

  • increased anxiety-related response(MP:0001363)

  • increased thermal nociceptive threshold(MP:0001973)

  • increased thigmotaxis(MP:0002797)

  • male infertility(MP:0001925)

  • oligozoospermia(MP:0002687)

  • postnatal growth retardation(MP:0001732)

  • reduced male mating frequency(MP:0001380)

  • small testis(MP:0001147)
    • Detailed phenotype data

    Ordering Information

    Donor DNASA (splicing acceptor site of the mouse zinc-finger gene Zfp40), E. coli neo, internal ribosome entry site (IRES) derived from encephalomyocarditis virus, SV40 nuclear transporting signal, E. coli lacZ gene, polyA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsThe BIOLOGICAL RESOURCE shall be used only for academic research purposes by a non-profit organization.
    The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL RESOURCE for purposes of other than academic research.
    In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi Chemical Corporation.
    The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical Corporation of RECIPIENT organization, RECIPIENT name, the specific research purpose and the date of distribution.
    DepositorTakashi Takeuchi (Mitsubishi Kasei Institute of Life Sciences)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityLive mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data