BRC No.RBRC03163
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6J.129P2-Hmox1<tm1Mym>
Former Common nameHO-1 floxed mouse
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6JJmsSlc
Strain developmentDeveloped by Masayuki Yamamoto, Center for Tsukuba Advanced Research Alliance, Tsukuba University in 2001. E14 ES cells were used. The mutant mice were backcrossed to C57BL/6 (C57BL/6JJcl and C57BL/6JJmsSlc).
Strain descriptionHmox1 gene floxed mice. Exon 3 to 5 was flanked by loxP sites.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJmsSlc]
ReferencesTohoku J. Exp. Med., 216, 331-339 (2008). 19060448

Health Report

Examination Date / Room / Rack2013/09/02Room:3-DRack:C


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Hmox1heme oxygenase (decycling) 18Hmox1<tm1Mym>targeted mutation 1, Masayuki Yamamoto

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
DsRed2Red Fluorescent Protein (Discosoma sp.)8DsRed2

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP8loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP8loxP


Donor DNABacteriophage loxP sites, chimeric intron and splicing acceptor (from pRL-null), Discosoma sp. DsRed2 cDNA, SV40 polyA signal, mouse Heme oxygenase-1 genomic DNA
Research applicationCre/loxP system
Fluorescent Proteins/lacZ System
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Tohoku J. Exp. Med., 216, 331-339 (2008 ).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The DEPOSITOR should be a co-author in articles when the users publish their data using these mice for TWO years after provided to the RIKEN BRC. Users should contact the DEPOSITOR in the case of application for any patents with the results from these mice.
DepositorMasayuki Yamamoto (Tohoku University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genetic Background
Category I MTA: FP license of TBUSA
Lab HP (Japanese)
Genotyping protocol -PCR-

BRC mice in Publications

Parada E, Egea J, Buendia I, Negredo P, Cunha AC, Cardoso S, Soares MP, Lopez MG.
The microglial alpha 7 acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing HO-1 via Nrf2.
Antioxid. Redox Signal. (2013) 23311871

Schallner N, Pandit R, LeBlanc R 3rd, Thomas AJ, Ogilvy CS, Zuckerbraun BS, Gallo D, Otterbein LE, Hanafy KA.
Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1.
J. Clin. Invest. (2015) 26011640

Parada E, Buendia I, Navarro E, Avendañ C, Egea J, Lóez MG.
Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects.
Mol Nutr Food Res (2015) 26047311