Strain Data Sheet

RBRC03079

Strain Information

Image
BRC No.RBRC03079
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Reln<tm1.1Mhat>
Former Common nameReelin delta C-FLAG knock-in mouse
H-2 Haplotype
ES Cell lineBruce 4 [B6.Cg-Thy1<a>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
FLAG FLAG tag (synthetic)5FLAG
Reln
MGI:103022		reelin5Reln<tm1.1Mhat> targeted mutation 1.1, Mitsuharu Hattori
  • epilepsy, familial temporal lobe, 1(MedGEN)

  • familial temporal lobe epilepsy 7(MedGEN)

  • Norman-Roberts syndrome(MedGEN)
    • loxP phage P1 loxP5loxP

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal Purkinje cell morphology (MP:0000877)

  • abnormal cerebellar Purkinje cell layer (MP:0000875)

  • abnormal cerebral cortex morphology (MP:0000788)

  • abnormal cortical marginal zone morphology (MP:0000792)

  • abnormal dentate gyrus morphology (MP:0000812)
    • more 14 phenotypes
  • abnormal hippocampus CA1 region morphology (MP:0008263)

  • abnormal hippocampus morphology (MP:0000807)

  • abnormal social/conspecific interaction behavior (MP:0002557)

  • abnormal spatial working memory (MP:0008428)

  • behavior/neurological phenotype (MP:0005386)

  • decreased anxiety-related response (MP:0001364)

  • decreased body weight (MP:0001262)

  • ectopic Purkinje cell (MP:0000885)

  • enhanced exercise endurance (MP:0012107)

  • hyperactivity (MP:0001399)

  • increased stereotypic behavior (MP:0001409)

  • increased vertical activity (MP:0002574)

  • muscle weakness (MP:0000747)

  • nervous system phenotype (MP:0003631)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP, mouse Reln genomic DNA, FLAG tag (synthetic)
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 未定
    DepositorMitsuharu Hattori (Nagoya City University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data