Strain Data Sheet

RBRC02976

Strain Information

Image
BRC No.RBRC02976
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Ahrr<tm1Yfk>
Former Common name
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. Yoshiaki Fujii-Kuriyama, University of Tsukuba.
Strain descriptionAhR repressor (arly-hydrocarbon receptor repressor) gene knock-out mice. AhR repressor is an AhR-related bHLH-PAS transcription factor.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]Homozygous mutant mice are viable and fertile.
References
Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice.
Hosoya T, Harada N, Mimura J, Motohashi H, Takahashi S, Nakajima O, Morita M, Kawauchi S, Yamamoto M, Fujii-Kuriyama Y
Biochem. Biophys. Res. Commun., 365, 562-567 (2008). 18022386

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ahrraryl-hydrocarbon receptor repressor13Ahrrtargeted mutation 1, Yoshiaki Fujii-Kuriyama
lacZbeta-galactosidase (E. coli)13
neoneomycin resistance gene (E. coli)13Herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased incidence of tumors by chemical induction(MP:0004502)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Ahrr genomic DNA, E. coli lacZ, E. coli neo, herpes simplex virus thymidine kinase promoter (HSV tk promoter)
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochem. Biophys. Res. Commun., 365, 562-567 (2008). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to include the DEPOSITOR as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during first TWO years after deposition by the DEPOSITOR to the RIKEN BRC. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorYoshiaki Fujii (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data