Strain Data Sheet

RBRC02901

Strain Information

Image
BRC No.RBRC02901
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S4-Masp1<tm1Tefu>
Former Common nameMASP1/3KO, Masp1/3-/-
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway.
Takahashi M, Iwaki D, Kanno K, Ishida Y, Xiong J, Matsushita M, Endo Y, Miura S, Ishii N, Sugamura K, Fujita T
J. Immunol., 180, 6132-6138 (2008). 18424734

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Masp1MBL associated serine protease 116Masp1targeted mutation 1, Teizo Fujita
  • 3MC syndrome 1(MedGEN)
    • neoneomycin resistance gene (E. coli)16mouse phosphoglycerate kinase promoter (PGK promoter)
  • 3MC syndrome 1(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • decreased body weight(MP:0001262)

  • decreased survivor rate(MP:0008770)

  • impaired complement alternative pathway(MP:0002472)

  • impaired lectin complement pathway(MP:0009062)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Masp1 genomic DNA
    Research applicationCell Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 180, 6132-6138 (2008).The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. If the RECIPIENT submit any results that are obtained from the BIOLOGICAL RESOURCE to research journals, the DEPOSITOR/DEVELOPER must be added as co-authors in the first publication. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorTeizo Fujita (Fukushima Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data