Strain Data Sheet

RBRC02891

Strain Information

Image
BRC No.RBRC02891
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Ovol2<tm1Iiu>
Former Common nameOvo12-KO, Movo-KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.
Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S
Genes Cells 12, 773-785 (2007). 17573777

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ovol2ovo like zinc finger 22Ovol2targeted mutation 1, Seiji Ito
  • posterior polymorphous corneal dystrophy 1(MedGEN)
    • loxPphage P1 loxP2loxP
  • posterior polymorphous corneal dystrophy 1(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal angiogenesis(MP:0000260)

  • abnormal aortic sac morphology(MP:0012510)

  • abnormal blood circulation(MP:0002128)

  • abnormal embryonic tissue morphology(MP:0002085)

  • abnormal endocardium morphology(MP:0003974)
    • more 19 phenotypes
  • abnormal extraembryonic tissue morphology(MP:0002086)

  • abnormal heart development(MP:0000267)

  • abnormal heart looping(MP:0000269)

  • abnormal heart ventricle morphology(MP:0005294)

  • abnormal placenta vasculature(MP:0003231)

  • abnormal placental labyrinth vasculature morphology(MP:0008803)

  • abnormal vasculogenesis(MP:0001622)

  • abnormal vitelline vascular remodeling(MP:0004076)

  • abnormal vitelline vasculature morphology(MP:0003229)

  • absent intersomitic vessels(MP:0012254)

  • absent myocardial trabeculae(MP:0000293)

  • absent pharyngeal arches(MP:0003874)

  • absent vitelline blood vessels(MP:0001719)

  • decreased embryo size(MP:0001698)

  • embryonic growth retardation(MP:0003984)

  • embryonic lethality during organogenesis, complete penetrance(MP:0011098)

  • hemorrhage(MP:0001914)

  • open neural tube(MP:0000929)

  • small heart(MP:0002188)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP site, mouse Ovo12 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Cells, 12, 773-785 (2007).
    DepositorSeiji Ito (Kansai Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data