Strain Data Sheet

RBRC02886

Strain Information

Image
BRC No.RBRC02886
TypeCongenic
SpeciesMus musculus
Strain nameEOD/ThpNkc-Cno<cno-II>/Nkc
Former Common nameMutant-EOD (mut-EOD)
H-2 Haplotype
ES Cell line
Background strainEOD [MRL, BXSB]
Appearance
Strain development
Strain description
Colony maintenance
References
Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis.
Yoshida M, Saiga K, Hato T, Iwaki S, Niiya T, Arita N, Komori H, Tsubaki T, Furukawa H, Terada M, Maeyama K, Nemoto K, Nose M, Ono M
Arthritis Rheum., 54, 2934-2943 (2006). 16948132

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
FasFas cell surface death receptor19Fas
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)
    • Cnocappuccino5Cno
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)
    • Yaaaccelerated autoimmunity and lymphoproliferation transpositionYYaaaccelerated autoimmunity and lymphoproliferation
  • autoimmune lymphoproliferative syndrome type 1(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal choroid pigmentation(MP:0005100)

  • abnormal kidney physiology(MP:0002136)

  • abnormal liver physiology(MP:0000609)

  • abnormal melanogenesis(MP:0005077)

  • abnormal melanosome morphology(MP:0005075)
    • more 18 phenotypes
  • abnormal optic choroid morphology(MP:0005098)

  • abnormal platelet dense granule physiology(MP:0009446)

  • abnormal postural reflex(MP:0002980)

  • abnormal retina pigmentation(MP:0005103)

  • abnormal vesicle-mediated transport(MP:0008546)

  • decreased eye pigmentation(MP:0005172)

  • decreased lysosomal enzyme secretion(MP:0003173)

  • decreased platelet ATP level(MP:0009448)

  • decreased platelet aggregation(MP:0009549)

  • decreased platelet calcium level(MP:0004867)

  • decreased platelet dense granule number(MP:0020432)

  • decreased platelet serotonin level(MP:0004725)

  • diluted coat color(MP:0000371)

  • head tilt(MP:0005191)

  • hypopigmentation(MP:0005408)

  • impaired balance(MP:0001525)

  • increased bleeding time(MP:0005606)

  • respiratory system phenotype(MP:0005388)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDermatology Research
    Immunology and Inflammation Research
    Mouse Models for Human Disease
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Arthritis Rheum., 54, 2934-2943 (2006). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorNippon Kayaku (Nippon Kayaku Co., Ltd)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data