Strain Data Sheet

RBRC02870

Strain Information

Image
BRC No.RBRC02870
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(DBH-IL2RA)5-1Koba
Former Common nameDIL
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Dr. Kazuto Kobayashi, Fukushima Medical University School of Medicine in 1995. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J.
Strain descriptionDBH-IL2RA transgenic mice that contain a uman Interleukin-2 receptor α subunit under control of the human DBH gene promoter.
Colony maintenance
References
Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.
Kobayashi K, Morita S, Sawada H, Mizuguchi T, Yamada K, Nagatsu I, Fujita K, Kreitman R J, Pastan I, Nagatsu T
Proc. Natl. Acad. Sci. USA, 92, 1132-1136 (1995). 7862648

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
IL2RAInterleukin-2 receptor α-subunit (human)UNIL2RAhuman dopamine beta hydroxylase (DBH) promoter
poly ApolyAUNpoly A
poly ASV40 polyA signalUNpoly A

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman DBH gene promoter, human Interleukin-2 receptor α subunit, SV40 polyA signal, rabbit 2nd intron and polyA signal
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 92, 1132-1136 (1995).
    DepositorKazuto Kobayashi (Fukushima Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data