BRC No.RBRC02849
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Ern1<tm1Dron>
Former Common nameIrel alpa knockout mouse +/- strain:129/C57BL/Black Swiss Webster
H-2 Haplotype
ES Cell line
Background strain
Appearanceblack [a/a B/B C/C]
Strain developmentDeveloped by Dr. David Ron, New York University School of Medicine. Gene targeting was achieved in W4 ES cells.
Strain descriptionErn1, endoplasmic reticulum (ER) to nucleus signaling 1 gene knock-out mice. Homozygous Ern1 mutant mice are embryonic lethal during organogenesis.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]Homozygotes are embryonic lethal.
ReferencesScience, 287, 664-666 (2000). 10650002
Nature, 415, 92-96 (2002). 11780124

Health Report

Examination Date / Room / Rack2010/07/05Room:4-5Rack:B


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Ern1endoplasmic reticulum (ER) to nucleus signaling 111Ern1<tm1Dron>targeted mutation 1, David Ron

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)11mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNAmouse Ern1 genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin phosphotransferase
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Science, 287, 664-666 (2000). Nature, 415, 92-96 (2002).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. DEPOSITOR hereby excludes any and all warranties, implied or express, including warranties of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE or of non-infringement of patents or other proprietary right. The sample of BIOLOGICAL RESOURCE is provided "as is". In no event shall DEPOSITOR be liable for direct, indirect, special, incidental or consequential damages in connection with the BIOLOGICAL RESOURCE. RECIPIENT and RIKEN BRC will indemnify and hold DEPOSITOR harmless from any claims or liability resulting from the use of the BIOLOGICAL RESOURCE by you. Prior to filing an application for a patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE, the recipient shall acquire the consent form the DEPOSITOR for such application.
DepositorDavid Ron (New York University School of Medicine)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data